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Gamma-glutamyl hydrolase : ウィキペディア英語版 | Gamma-glutamyl hydrolase
Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction: : Hydrolysis of a gamma-glutamyl bond This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. In humans, gamma-glutamyl hydrolase is encoded by the ''GGH'' gene.〔〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8836 )〕 This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.〔 == Nomenclature ==
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
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